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Treatment Name: Trifluridine and Tipiracil (Lonsurf®)

Trifluridine and Tipiracil (Lonsurf®) is a Chemotherapy Regimen for Colon Cancer

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The ChemoExperts Team


1) Mayer RJ,  Van Cutsem E,  Falcone A, et al. Randomized  trial  of  TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 2015;372:1909-1919.

Created: February 16, 2019 Updated: February 16, 2019

What is Colon Cancer?

A disease of the cells from the large intestine.  Colon cancer is the third most common cancer among both men and women.  Known causes include:  family history, poor diet, sedentary lifestyle, obestity, diabetes, history of colon polyps, smoking, heavy alcohol use, prior radiation treatment to abdomen for other cancers, and old age.  The stage can vary at diagnosis and throughout treatment.  Stages of colon cancer use Tumor, Node, Metastasis (TNM) staging as well as Stage Grouping using Stages I, II, III, or IV.  The effectiveness of the treatment may depend upon the stage at diagnosis.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Common Trifluridine and Tipiracil (Lonsurf®) starting doses

Usual starting dose: three to four oral tablets by mouth twice daily on Days 1, 2, 3, 4, 5 and then on Days 8, 9, 10, 11, and 12