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Treatment Name: Ribociclib (Kisqali®) + Fulvestrant (Faslodex®)

Ribociclib (Kisqali®) + Fulvestrant (Faslodex®) is a Treatment Regimen for Breast Cancer - metastatic

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References

1) Slamon DJ, Neven P, Chia S, et al. Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3. J Clin Oncol. 2018;36:2465-2472.

Created: February 16, 2019 Updated: February 16, 2019

What is Breast Cancer - metastatic?

What is Metastatic Breast Cancer?
A disease of the milk-producing glands known as lobules, milk ducts, or other cells found in the breast. Metastatic breast cancer is one that has moved from the breast to other areas of the body, which may include the brain, liver, or bone. Breast cancer is one of the most common types of cancers in women, but may rarely affect men as well. Known causes of breast cancer include genetic causes, such as the BRCA mutation, or obesity. The effectiveness of the treatment may depend upon the stage at diagnosis.

Types of metastatic breast cancer:
1. Hormone-receptor positive or negative (60 - 65% of patients)

  • Estrogen Receptor positive (ER)+ or negative (ER)-
  • Progestin Receptor positive (PR)+ or negative (PR)-

2. Hormone Epidermal growth factor Receptor-2 (HER-2) positive or negative (20 - 25% of patients)

  • HER-2 +
  • HER-2 -

3. Triple Negative (15 - 18% of patients)

  • ER- and PR- and (HER-2)-
NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Common starting doses for Ribociclib (Kisqali®) + Fulvestrant (Faslodex®)

  • Usual ribociclib starting dose: 600 mg (three 200 mg tablets) by mouth daily for 21 consecutive days, followed by a 7-day no ribociclib rest period
  • Fulvestrant intramuscular (I.M.) injection weekly for 3 weeks, then monthly thereafter