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Treatment Name: Dasatinib (Sprycel®)

Dasatinib (Sprycel®) is a Chemotherapy Regimen for Acute Lymphoid Leukemia (ALL)

How does dasatinib (Sprycel®) work?

Dasatinib is designed to stop cancerous white blood cells from growing and dividing. It may also permit non-cancerous blood cells in the bone marrow to grow normally.

Goals of dasatinib (Sprycel®) therapy:

Dasatinib (Sprycel®) is taken to reduce symptoms from ALL or prevent them from ever occurring, but is not commonly given with the goal of cure.


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How is Dasatinib for ALL taken?

  • Dasatinib (Sprycel®) 140 mg oral tablet by mouth ONCE daily, every day

Dasatinib is usually dispensed by a pharmacy and taken at home. Some patients may require hospitalization when initially diagnosed and begin treatment before leaving the hospital. Typical duration of therapy is usually life-long.

It is important that you do not miss doses, unless your doctor specifically says it is okay. Missing doses may prevent you from achieving a response and increase the risk of dasatinib no longer working.

Note: Individual doses may vary based upon your Doctor's recommendation, or drug availability

Side Effects

What are the most common side effects of dasatinib (Sprycel®) when taken by patients for ALL?

In clinical studies, the most commonly reported dasatinib (Sprycel®) side effects are shown here:

  • Anemia [low red blood cell count] (100%)
  • Low platelet count [thrombocytopenia] (92%)
  • Low white blood cells [neutropenia] (85%)
  • Diarrhea (35%)
  • Water retention (30%)
    • General swelling (21%)
    • Fluid in lungs (18%)
  • Nausea (28%)
  • Vomiting (20%)
  • Infection (18%)
  • Bleeding (15%)
  • Fever (15%)
  • Neutropenic fever (13%)
  • Muscle pain (13%)
  • Shortness of breath (10%)
  • Upset stomach (10%)
  • Fatigue (10%)
  • Headache (10%)
  • Weight loss (8%)
  • Rash (5%)

Some of the side effects listed may be due to ALL, rather than dasatinib. The percentage of patients that stopped using dasatinib due to unacceptable side effects is about 5%.

Watch videos on common dasatinib (Sprycel®) therapy side effects below

Side effect videos Side Effect Videos
AnemiaAnemiaDiarrheaDiarrheaNausea and VomitingNausea and VomitingBleedingBleedingNeutropenic FeverNeutropenic FeverPainPainFatigue Fatigue


How often is monitoring needed with dasatinib treatment?

Labs (blood tests) may be checked before treatment, once weekly during the first month, then every other week for the first three months, then monthly until stable. Labs at diagnosis often include: Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), Lactate Dehydrogenase (LDH), magnesium, phosphorus, and uric acid, plus any others your doctor may order. Tumor lysis syndrome is usually not seen after the first two weeks of therapy.

Additionally, your doctor will order a test known as BCR/ABL. Your doctor uses the BCR/ABL% to monitor your response to dasatinib.

How do I know if I am responding to dasatinib?

It is important for you to know what your BCR/ABL% is. This way, if it begins to increase, you will know and can look for reasons why.

How often is imaging needed with dasatinib therapy?

Imaging may be checked before treatment, and periodically thereafter. Imaging may include: a chest X-ray, or CT scan of the lungs. These are most often done to look for fluid in the lungs or an infection causing pneumonia.

How might blood test results/imaging affect treatment with dasatinib therapy?

Depending upon the results, your doctor may advise to interrupt dasatinib (Sprycel®) therapy for a short period of time (several days), decrease the dose if the normal blood cells are too low, or switch therapy if goals of therapy are not being met.

ChemoExperts Tips

  • Dasatinib (Sprycel®) may be taken with or without food. The best time of day to take it is when it is easiest to remember
  • Dasatinib may decrease in effectiveness if taken with medicines for heartburn or those that reduce stomach acid. Talk with your doctor or pharmacist about how best to take these two medicines together
  • Excess fluid in the lungs, known as a pleural effusion, is a serious and somewhat common side effect of dasatinib. Some patients may require an emergency room or hospital visit to drain the extra fluid from the lungs if it is difficult to breathe. On occasion, the extra fluid can be managed by not taking dasatinib for several days, but this should only be done under a doctor's supervision. Diuretics may also help get rid of extra fluid in the lungs
  • A chemical in grapefruit juice, star fruit, and pomegranate can decrease the body’s ability to break down dasatinib and increase the amount of dasatinib in your body. This may lead to an an increase in side effects, therefore it is best to avoid these fruits
  • Although rash is somewhat common, it is rarely severe. When rash occurs, it usually appears on the forearms, chest, abdominal area, and occasionally on the face. In most cases, therapy with dasatinib can be continued and the rash will go away on its own or with topical creams or lotions recommended by your doctor
  • Bring all of your pill bottles to every clinic visit! This will make it easier for your healthcare team to make sure dasatinib can be taken safely with all other medications you are taking. A pharmacist should ALWAYS review your medication list to ensure that drug interactions are prevented or managed appropriately
  • If you are having trouble paying for dasatinib (Sprycel®), there are many patient assistance programs available to help. Ask your doctor or pharmacist to help you with this before you run out!
  • Clinical trials may exist for ALL. Ask your doctor if any studies are currently enrolling in your area. If not, go to to search for other centers offering study medications

Patient Assistance & Co-payment Coverage

Patients under the age of 65 years, or those with private insurance plans:
If you have insurance and are looking for patient assistance or copay assistance for Dasatinib (Sprycel®), we have provided links that may help.

Visit our Patient Assistance page and click the links to various patient assistance programs for help paying for Dasatinib (Sprycel®). Depending upon your income, they may be able to help cover the cost of:

  • Dasatinib

For Branded medications (may be available for generic medications too), check with the manufacturer to determine if a co-pay card is offered and if it could reduce your monthly copay.

  • If you are uninsured, check with the manufacturer to determine if you are eligible to receive medication at no cost.

Medicare and Medicaid patients (Patients 65 years or older):
The clinic providing treatment will likely pre-authorize medications and immune therapies such as Dasatinib (Sprycel®) and are the best source to help you understand drug cost.

  • Ask to speak with a patient assistance technician or financial counselor at the clinic or hospital administering this therapy.

Emotional Wellness

What is Emotional Wellness?
Emotional wellness is having a positive outlook balanced with a realistic understanding of current life events. This requires both an awareness and acceptance of your emotions. It is with this knowledge that you can develop a plan to take the necessary actions to positively impact your life.

Emotional wellness uses an ongoing process to continually reflect on the stressors of life in a constructive manner to move forward and create happiness.

Because emotional wellness is deeply connected with physical, social, and spiritual wellness, pursuing it often becomes particularly difficult in times of major illness. Despite this difficulty, working toward emotional wellness has been connected to improved treatment outcomes and a higher likelihood of achieving goals of therapy.

Learn more about pursuing emotional wellness while receiving treatment with Dasatinib (Sprycel®)

Individual Drug Label Information

Dasatinib (Sprycel®)

  • Dasatinib is an oral tablet that comes in strengths of 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, and 140 mg 
  • Dasatinib can be taken with or without food and with a large glass of water. If you miss a dose, and it is within 12 hours from the regular time you take it, you may still take it. If it is more than 12 hours late, skip it, and take the next scheduled dose at the regular time. Do not take two doses at the same time 
  • Dasatinib should be stored at room temperature, 68°F to 77°F  (20°C to 25°C) 
  • Dosage adjustments may be required if good white blood cells (neutrophils), red blood cells, or platelets fall below the normal range  
  • Women of child-bearing potential should avoid becoming pregnant while taking dasatinib or taking it in the first trimester of pregnancy as it may harm the unborn baby. Women wanting to become pregnant should consult their doctor regarding the safest way to balance this with dasatinib therapy  
  • May interact with a steroid known as dexamethasone (Decadron), or a variety of anti-seizure medicines. A dosage increase is sometimes required to avoid losing response to dasatinib  
  • A chemical in grapefruit juice decreases the body’s ability to break down dasatinib so it is best to avoid grapefruit and grapefruit juice to help prevent an increase in side effects  
  • May interact with medicines taken for heartburn or those that reduce stomach acid. It is recommended that short-acting antacids (example: Tums®) be considered instead of proton pump inhibitors (example: omeprazole (Prilosec®)) or H2-antagonists (famotidine, ranitidine). Tums® should not be taken within 2 hours of dasatinib
General Dasatinib (Sprycel) Side Effects 
  • Water retention is common. Patients should weigh themselves daily and keep a journal to show their doctor, who may then prescribe diuretics or recommend withholding treatment for a short time 
  • Muscle cramps can sometimes be treated with electrolytes such as potassium or magnesium prescribed by your doctor 
  • Low platelet count. Increased bruising or bleeding may be a clue to a low platelet count 
  • Nausea, vomiting, and upset stomach may be minimized by taking with food 
  • Diarrhea often resolves with continued treatment and responds to over-the-counter medicine. Skin rash often resolves with continued treatment. Tell your doctor immediately if you develop a rash 
  • Fatigue 
  • Fever may be a sign of infection. Keep a thermometer at home and report any fevers immediately 
  • Click on the dasatinib (Sprycel) package insert below for reported side effects and possible drug interactions

Side Effect Videos
Nausea and VomitingNausea and VomitingDiarrheaDiarrheaFatigue Fatigue BleedingBleedingPainPain

See DailyMed package insert.

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1. Lilly MB, Ottmann OG, Shah NP, et al. Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study. Am J Hematol 2010;85:164-170

Created: April 3, 2020 Updated: April 3, 2020

What is Acute Lymphoid Leukemia (ALL)?

Acute Lymphoid Leukemia (ALL), also known as acute lymphoblastic leukemia, is a disease of the lymphoid cells found in the bone marrow. Lymphoid cells are responsible for developing into cells of the immune system called B-cells, T-cells, or Natural Killer cells. In ALL, immature lymphoid cells know as "blasts" replicate at a very fast rate. Sometimes blasts crowd out the normal cells in the bone marrow so that red blood cells or platelets are unable to develop.

Common symptoms of ALL include fatigue, infection, and bruising or bleeding. ALL is the most common cancer diagnosed in children, but is rare in adults. Most cases of ALL are considered "de novo" meaning that the cause is unknown; however, some cases can be linked to certain genetic syndromes. There is no staging system for ALL. Chromosomes are often analyzed to determine which mutations in the chromosomes exist. The effectiveness of the treatment may depend upon the specific chromosome mutations that are present.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose your therapy.

What is BCR/ABL?

A gene mutation within CML cells. The percent of cells that have the BCR/ABL mutation goes down by taking dasatinib therapy. The goal is that the percentage will become undetectable. This happens in many patients and is known as a complete molecular response, or 0.000%. At diagnosis, the BCR/ABL% is often very high, sometimes exceeding 100%. This is because the test is based upon the average BCR/ABL% from patients in one of the earliest clinical studies with imatinib. Having a BCR/ABL% greater than 100% at diagnosis does not usually affect the response to dasatinib.

What are diuretics?

Diuretics are medicines used to make people urinate. They are usually taken to help get rid of excess water in the body. Excess water usually appears as swelling in the extremities such as arms, legs, or feet. It can occur in other areas such as the lungs or around the eyes.

What is Tumor Lysis Syndrome?

Tumor lysis syndrome occurs when many cancer cells die quickly and release their contents into the bloodstream. Many times the body has the ability to flush these substances out through the kidneys or metabolize them via the liver. However, sometimes the body needs medicines to help eliminate these substances and to prevent organ damage.

What is a Pleural Effusion?

Pleural effusion is when fluid builds up in the sack surrounding the lungs making it difficult for the lungs to expand. This makes it harder to breathe or take a deep breath. Depending upon the severity of fluid build-up, pleural effusion may be managed by holding dasatinib therapy until the fluid is gone, a dose reduction, taking water pills known as diuretics, corticosteroids (example: prednisone). On occasion, the fluid may have to be drained with a needle (therapeutic thoracentesis).

What is a CBC?

A Complete Blood Count (CBC) is a frequently ordered blood test that tells clinicians the status of your: 1) White blood cell count, 2) Hemoglobin, and 3) Platelet count at the time the test was taken.

Common uses:
1) White blood cell count (WBC): is used to determine infection risk, or response to chemotherapy. Certain chemotherapy agents may harm our good infection-fighting cells. Sometimes chemotherapy may need to be delayed to allow these cells to recover.

2) Hemoglobin: is used to determine if someone is anemic. Anytime the hemoglobin is below 12 g/dL, the person is said to be anemic. Red blood cell transfusions, and sometimes iron can be given to restore the hemoglobin level, but anemia treatment should always aim at treating the underlying cause or condition.

3) Platelet count: is used to determine if the risk of bleeding is increased or if a platelet transfusion is required to prevent bleeding. Certain medications that increase bleeding risk, such as: aspirin, certain chemotherapy agents, and blood thinners, may need to be stopped temporarily until the platelet count is within a safe range.

What is a CMP?

A Comprehensive Metabolic Panel (CMP) is a frequently ordered blood test that tells clinicians the status of your: 1) Electrolytes & Acid/Base status2) Kidney function, 3) Liver function, 4) Blood sugar, and 5) Calcium at the time the test was taken. It is commonly used to monitor liver and kidney function when beginning new medications such as chemotherapy. A total of 14 tests are run simultaneously and are shown below.

Electrolytes & Acid/Base status:
1) Sodium, 2) Potassium, 3) Carbon dioxide, 4) Chloride

Kidney Function:
5) BUN (blood urea nitrogen), 6) Serum creatinine (Scr)

Liver Function:
7) AST, 8) ALT, 9) Total bilirubin, 10) Alk Phos, 11) Albumin, 12) Total protein

Blood sugar:
13) Serum glucose

14) Serum calcium

What does Cure mean?

The word “cure” means there are no cancer cells left in the body and cancer will never come back. Depending on the cancer type and stage, this may be the true goal of therapy. However, it is very difficult to prove all cancer cells are gone. Even though images, like X-rays and MRI’s, and blood tests may not show any signs of cancer, there can be a small amount of cancer cells still left in the body. Because of this, the word “remission” is used more often. This means there are no signs or symptoms of cancer. Patients in remission are followed closely for any signs of cancer returning. Sometimes, more chemotherapy may be given while in remission to prevent the cancer from coming back.

Doctors usually do not consider a patient “cured” until the chance of cancer returning is extremely low. If cancer does return, it usually happens within 5 years of having a remission. Because of this, doctors do not consider a patient cured unless the cancer has not come back within 5 years of remission. The five-year cutoff does not apply to all cancers.