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Cancer Types

Systemic Mastocytosis

What is Systemic Mastocytosis?
A disease of the mast cells that can be found in the skin, internal organs (liver, spleen, GI tract, lymph nodes), and bone marrow. Mast cells can release various chemicals into the body that can produce symptoms of a serious allergic reaction. When these substances cause organ damage, these types of symptoms are known as “C findings,” and include low blood cell counts such as anemia (low red blood cells) or thrombocytopenia (low platelets), liver problems, weight loss, swelling in abdomen, and bone lesions.

Mastocytosis is a very rare condition that is most commonly caused by a mutation in a protein called “KIT” that causes mast cells to grow and divide. There are various subtypes of mastocytosis, which can vary at diagnosis and throughout treatment.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Treatment Options

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Created: May 1, 2017 Updated: May 1, 2017


Gotlib J, Kluin-Nelemans HC, George TI, et al. Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis. N Engl J Med. 2016;374:2530-2541.