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Side Effect: Cytokine Release Syndrome (CRS)

What is Cytokine Release Syndrome (CRS)?

What does Cytokine Release Syndrome (CRS) look like?

The symptoms of CRS can vary depending upon the severity of the condition, but may include:

In more severe cases, patients may experience:

Who gets Cytokine Release Syndrome (CRS)?

How to prevent Cytokine Release Syndrome (CRS)

How to treat Cytokine Release Syndrome (CRS)

The treatment of CRS involves early and quick supportive care measures.


1. Santomasso BD, Nastoupil LJ, Adkins S, et al. Management of Immune-Related Adverse Events in Patients Treated With Chimeric Antigen Receptor T-Cell Therapy: ASCO Guideline. J Clin Oncol 2021 Dec;39(35):3978-3992.

2. Brudno JN, Kochenderfer JN. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood 2016;127(26):3321-3330.

Created: May 3, 2024 Updated: May 3, 2024