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Treatment Name: PETHEMA Consolidation #3 (ATRA + Idarubicin + Cytarabine)

PETHEMA Consolidation #3 (ATRA + Idarubicin + Cytarabine) is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL)

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References

1) Sanz MA, Montesinos P, Rayón C, et al. Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome. Blood. 2010;115:5137-5146.

Created: March 7, 2019 Updated: March 7, 2019

What is Acute Promyelocytic Leukemia (APL)?

Acute Promyelocytic Leukemia (APL) is a type of acute leukemia that affects a specific type of white blood cell known as promyelocytes, which are found in the bone marrow. APL is a rare condition. The cause of APL is unknown. It can present as low, intermediate, or high-risk disease. The effectiveness of the treatment may depend upon the risk category (low, intermediate, or high) at diagnosis. APL is highly curable when appropriate treatment is not delayed.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Common PETHEMA Consolidation #3 starting doses

  • Oral ATRA (Tretinoin): 45 mg/m2/day (in two divided doses, rounded to 10 mg capsule size). ATRA is taken by mouth morning and night on Days 1 through 15
  • Idarubicin 12 mg/m2 intravenous (I.V.) infusion over 10 to 15 minutes on Day 1
  • Cytarabine 150 mg/m2 subcutaneous injection given every 8 hours on Days 1, 2, 3, and 4