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Treatment Name: HyperCVAD Part B + Imatinib (Gleevec®)

HyperCVAD Part B + Imatinib (Gleevec®) is a Chemotherapy Regimen for Acute Lymphoid Leukemia (ALL)

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1) Thomas DA, Faderl S, Cortes J, et al. Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood. 2004;103:4396-4407.

Created: February 18, 2019 Updated: February 18, 2019

What is Acute Lymphoid Leukemia (ALL)?

Acute Lymphoid Leukemia (ALL), also known as acute lymphoblastic leukemia, is a disease of the lymphoid cells found in the bone marrow. Lymphoid cells are responsible for developing into cells of the immune system called B-cells, T-cells, or Natural Killer cells. In ALL, immature lymphoid cells know as "blasts" replicate at a very fast rate. Sometimes blasts crowd out the normal cells in the bone marrow so that red blood cells or platelets are unable to develop.

Common symptoms of ALL include fatigue, infection, and bruising or bleeding. ALL is the most common cancer diagnosed in children, but is rare in adults. Most cases of ALL are considered "de novo" meaning that the cause is unknown; however, some cases can be linked to certain genetic syndromes. There is no staging system for ALL. Chromosomes are often analyzed to determine which mutations in the chromosomes exist. The effectiveness of the treatment may depend upon the specific chromosome mutations that are present.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose your therapy.

Common HyperCVAD Part B + Imatinib (Gleevec®) starting doses

  • Imatinib 400 mg by mouth once daily on Days 1 through 14
  • Methotrexate 1000 mg/m2 intravenous (I.V.) infusion, usually given over 24 hours on Day 1
  • Cytarabine 3000 mg/m2 I.V. infusion, usually given over two hours, every 12 hours on Days 2 and 3 (four doses per Cycle)
  • Leucovorin I.V. infusion or 15 mg to 50 mg oral tablet, starts 12 hours after the end of methotrexate infusion and continues every 6 hours until the level of methotrexate in the blood decreases to a safe level
  • Prednisolone eye drops. 2 drops in each eye every six hours, started before the first dose of cytarabine and finishing 72 hours after completing the last dose