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Treatment Name: HyperCVAD Part A + Rituximab

HyperCVAD Part A + Rituximab is a Chemotherapy Regimen for Acute Lymphoid Leukemia (ALL)

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1) Thomas DA, O'Brien S, Faderl S, et al. Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia. J Clin Oncol. 2010;28:3880-3889.

Created: February 21, 2019 Updated: February 21, 2019

What is Acute Lymphoid Leukemia (ALL)?

Acute Lymphoid Leukemia (ALL), also known as acute lymphoblastic leukemia, is a disease of the lymphoid cells found in the bone marrow. Lymphoid cells are responsible for developing into cells of the immune system called B-cells, T-cells, or Natural Killer cells. In ALL, immature lymphoid cells know as "blasts" replicate at a very fast rate. Sometimes blasts crowd out the normal cells in the bone marrow so that red blood cells or platelets are unable to develop.

Common symptoms of ALL include fatigue, infection, and bruising or bleeding. ALL is the most common cancer diagnosed in children, but is rare in adults. Most cases of ALL are considered "de novo" meaning that the cause is unknown; however, some cases can be linked to certain genetic syndromes. There is no staging system for ALL. Chromosomes are often analyzed to determine which mutations in the chromosomes exist. The effectiveness of the treatment may depend upon the specific chromosome mutations that are present.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose your therapy.

Common HyperCVAD Part A + Rituximab (Rituxan®) starting doses

  • Rituximab intravenous (I.V.) infusion on Days 1 and 11. The time of infusion varies depending upon tolerability
  • Cyclophosphamide 300 mg/m2 I.V. infusion, usually given over 3 hours, every 12 hours (twice daily) on Days 1, 2, and 3 (six doses total)
  • Mesna 600 mg/m2 I.V. infusion, usually given over 24 hours on Days 1, 2, and 3, ending on Day 4
  • Vincristine 2 mg I.V. infusion, usually given over 15 minutes on Days 4 and 11
  • Doxorubicin 50 mg/m2 I.V. infusion, given over 2 - 24 hours (infusion time depends upon hospital guidelines) on Day 4
  • Dexamethasone 40 mg (ten x 4 mg) oral tablet by mouth on Days 1, 2, 3, 4 and 11, 12, 13, 14