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Treatment Name: Carboplatin + Pemetrexed (Alimta®) + Bevacizumab (Avastin®)

Carboplatin + Pemetrexed (Alimta®) + Bevacizumab (Avastin®) is a Chemotherapy Regimen for Lung Cancer, Non-Small Cell Lung Cancer (NSCLC)

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References

1) Patel JD, Socinski MA, Garon EB, et al. Pointbreak: a randomized phase III study of pemetrexed plus carboplatin and bevacizumab followed by maintenance pemetrexed and bevacizumab versus paclitaxel plus carboplatin and bevacizumab followed by maintenance bevacizumab in patients with 3 stage IIIB or IV nonsquamous non-small cell lung cancer. J Clin Oncol. 2013;31:4349-4357.

Created: March 13, 2019 Updated: March 13, 2019

What is Lung Cancer, Non-Small Cell Lung Cancer (NSCLC)?

What is Non-Small Cell Lung Cancer?
A disease of the tissue found in the lung.  Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Known causes include smoking and exposure to environmental toxins.  The stage of NSCLC can vary at diagnosis and throughout treatment.  Stages include stage I, II, III, and IV.  The effectiveness of the treatment may depend upon the stage at diagnosis.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Common Carboplatin + Pemetrexed (Alimta®) + Bevacizumab (Avastin®) starting doses

Induction:

  • Carboplatin AUC 6 intravenous (I.V.) infusion over 30 minutes on Day 1
  • Pemetrexed 500 mg/m2 I.V. infusion over 10 minutes on Day 1
  • Bevacizumab 15 mg/kg I.V. infusion over 90 minutes on Day 1 of Cycle 1
    • then over 60 minutes for Cycle 2, if no infusion reactions occur
    • then over 30 minutes for Cycles 3 and on, if no infusion reactions occur

Maintenance:

  • Pemetrexed 500 mg/m2 I.V. infusion over 10 minutes on Day 1
  • Bevacizumab 15 mg/kg I.V. infusion over 30 minutes on Day 1