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Treatment Name: ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) + Gemtuzumab Ozogamicin (Mylotarg®)

ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) + Gemtuzumab Ozogamicin (Mylotarg®) is a Treatment Regimen for Acute Promyelocytic Leukemia (APL)

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References

1) Abaza Y, Kantarjian H, Garcia-Manero G, et al. Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab. Blood. 2017;129:1275-1283.

Created: March 7, 2019 Updated: March 7, 2019

What is Acute Promyelocytic Leukemia (APL)?

Acute Promyelocytic Leukemia (APL) is a type of acute leukemia that affects a specific type of white blood cell known as promyelocytes, which are found in the bone marrow. APL is a rare condition. The cause of APL is unknown. It can present as low, intermediate, or high-risk disease. The effectiveness of the treatment may depend upon the risk category (low, intermediate, or high) at diagnosis. APL is highly curable when appropriate treatment is not delayed.

NOTE: Treatment Options listed below are not all-inclusive. Other treatments may be available. ChemoExperts provides drug information and does not recommend any one treatment over another. Only your Doctor can choose which therapy is appropriate for you.

Common ATRA + Arsenic Trioxide (Trisenox®) + Gemtuzumab Ozogamicin (Mylotarg®) starting doses

  • Oral ATRA (Tretinoin): 45 mg/m2/day (in two divided doses, rounded to 10 mg capsule size). ATRA is taken by mouth morning and night every day until hematologic complete remission is achieved
  • Arsenic Trioxide 0.15 mg/kg/day intravenous (I.V.) infusion infused over 2 hours once daily, every day, until hematologic complete remission is achieved
  • Gemtuzumab ozogamicin 9 mg/m2 I.V. infusion over 2 hours on Day 1